BIOL 201 Lecture Notes - Lecture 9: Inner Mitochondrial Membrane, Mitochondrial Matrix, Atp Synthase
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Without o2: everything will break down except for glycolysis. Tca cycle and etc stop, since nad+ (located inside mitochondrial membrane) is depleted. Since: as pyruvate enters mitochondria, it generates nadh in the first step. But it needs nad+ to do that, obviously! Without this substrate, the process cannot go on. Ofcourse, recall that co2 is also made in this first step but that"s irrelevant. Answer: electron shuttles that are on the inner membrane of mitochondria! Inner mitochondrial membrane is impermeable to nadh; nadh wants to go from cytosol into matrix but can"t, unless . So, cells have an enzyme called malate, which carries the electron from. Now, you have a stripped nad+ left in the cytosol. The electron that"s carried into the matrix by malate goes to a nad+ in the matrix and makes a nadh in the matrix. This is how you indirectly makes a nadh inside the matrix! As malate enters matrix, it takes e- with in.
