BIOL 201 Lecture 14: BIOL 201 cell biology and metabolism lecture 14
Document Summary
Biol 201 cell biology and metabolism-lecture 14 cell locomotion: contraction. Pick up the cell matter behind and move forward. Deadhesion and translocation of the focal adhesions: chemotaxis. Moving towards chemicals that attract the cell: cell move a constant velocity when there is constant actin concentration. The thickness of actin band at the cell front edge does not change. The filaments behind are constantly being disintegrated. How does cell direct the movement: e. g. amoeba that aggregates and form a fruiting body when under environmental stress. When a needle with substance that resemble the signal from a starving amoeba, the amoeba will move in that direction: rho family gtp trigger 3 types of actin network, rho-gtpase responds to outside signals. Rho-gdp in cytosol is an inactive form. Extracellular signal binds to receptor, triggers gef. Gef exchanging gdp by gtp and activate rho. Rho activates formin by relieving auto inhibition oh rho binding domain (rbd: cdc42 activates wasp and downstream.
