BIOL 201 Lecture Notes - Lecture 19: Ldl Receptor, Dynamin, Clathrin
11 Apr 2018
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Document Summary
Interdigitated between the organelles is the cytoskeleton (cytoskeleton is crowded) There is a constant flow and trafficking between endomembrane systems. If it wants to be flat, we"ll find some sort of ntpase activity (more specifically, Other forms of free energies can come from binding energy of proteins to membranes. If - g, this can be coupled to the + g of the membrane curving. The intrinsic curvature of the lipids: ex: Phosphorylcholine (pc) has parallel side-chains, making the lipid cylindrical . Proteins can force curvatures on membranes: consider the uptake of ldl particle from bloodstream. Ldl particles are recognized by the cells by receptors and endocytosed. Endocytosis occurs via clathrin-coated vesicle: ldl receptor recognises the apob belt of ldl particle. Recruits large number of proteins to inner surface of plasma membrane. Ex: ap2 complex, which recruits clathrin: clathrin bends the membrane around the receptor. Trimeric protein that oligomerizes into triskelion cage.
