BIOL 202 Lecture 3: Pedigrees and sex-linked inheritance January 12th

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First problem set is up on mycourses. Red: does not exhibit trait of interest. Xg: x chromosome with a dominant trait. Xg: x chromosome with a recessive trait. Heterozygous individuals (may or may not show the trait. A pedigree is a sort of family tree in which were are interested in studying the appearance of a certain phenotype. We can use pedigrees to deduce the genotype with accuracy. For example (class example): here is a cystic fibrosis pedigree. Cystic fibrosis is a rare, autosomal and recessive disease. We know it is recessive because the trait skips generations. We know it is autosomal because males and females are affected in equal or similar proportions. Steps to solving the pedigree: obvious genotypes: the affected individuals (iv-1 and iv-3). Since cystic fibrosis is recessive, they are homozygous recessive: In order to be homozygous recessive, individuals iv-2 and iv-4 must inherit the recessive (a) gene from both parents.

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