BIOL 300 Lecture Notes - Lecture 27: Phosphodiesterase, Adenylyl Cyclase, Adderall

• School: McGill University
• Department: Biology
• Course: BIOL 300
• Professor: Frieder Schoeck

Document Summary

Binding of hormone induces a conformation change in receptor. Activated receptor binds to g subunit: 3. Activated receptor causes conformation change in g , triggering dissociation of gdp (receptor is gef!: 4. Binding of gtp to g triggers dissociation of g both from the receptor and from g(cid:533)(cid:534: 5. G binds to effector, activating it: 6. G to dissociate from effector and reassociate with g(cid:533)(cid:534) The cholera toxin is a small molecule that binds to g -gtp and locks it in the active state. Gpcrs that modulate adenylyl cyclase: the fight or flight response is mediated by epinephrine binding to different. You need very little of that drug: 2. You affect a lot of different things at the same time because pka phosphorylates all kind of different enzymes. Termination of response: termination when there is a limited supply of ligand, 1.