BIOC 311 Lecture 10: Pyruvate Dehydrogenase (Part 2)
22 Oct 2015
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Document Summary
Sept. 28, 2015: side chains of aa can serve as acids or bases, they may play a role in oxidation-reduction. Endosymbiotic origins of mitochondria: features reflecting bacterial ancestry, double membrane structure: omm and imm, circular dna genome, mitochondrial protein synthesis is inhibited by chloramphenicol-like bacteria: Each mitochondrion contains 4-10 copies of this genome. Mitochondrial genome encodes 13 polypeptides: 11 for complexes i, iii and iv and 2 subunits of atp synthase, 22 trnas and ribosomal rna: 12s and 16s ribosomal rna for mitoribosomes: Resembles bacterial rrna (16s and 23s) vs. 18s and 28s for mammals. The other 1000 or so mitochondrial proteins are encoded by nuclear dna and imported into mitochondria nonessential and transfer of most essential genes to the nucleus. The mitochondrial genome was reduced in size by deletion of. The mitochondria is the main producer of reactive oxygen species. They can have very deleterious consequences on the cell (dna)
