BIOC 311 Lecture Notes - Lecture 13: Catabolism, Chief Operating Officer, Succinyl-Coa
23 Oct 2015
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Document Summary
Fate of 2 carbons of acetyl group: carboxymethyl carbons of the pro s arm of citrate always come from acetyl coa. Decarboxylation of pyruvate: pyruvate carboxylase (makes oaa) Carboxylation of pyruvate: pdc is switched off when energy charge is high: product inhibition by acetyl coa and. Nadh, which also activates pdh kinase - which phosphorylates e1 to shut it down. Regulation: cac is regulated by ratios: atp/adp, nadh/nad+, acetyl coa/coash, succinyl. Oct. 5, 2015: oxidation for atp generation, conversion to starting material for biosynthesis. When pyruvate carboxylase is active - usually due to depletion from biosynthesis - need to replenish: pyruvate is the most important branch point in the metabolism of a cell that is living on carbohydrate. Cac regulation: 3 key enzymes in cac important for regulation (irreversible, citrate synthase. Oct. 5, 2015: surplus citrate indicator of high energy charge. Alpha-ketoglutarate dehydrogenase: product inhibition: inhibited by nadh, succinyl coa, allosteric activation: calcium.
