INDS 111 Lecture Notes - Lecture 32: Targeted Therapy, Cancer Screening, Radiation Therapy
31 Dec 2018
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Document Summary
Risk-benefit- throw the window out of the window. Incidence, geographic distribution, and behavior of specific cancers are related to sex, age, race, genetic predisposition, and exposure to environmental carcinogens (most important), some viruses. Tumor suppressor genes may be deleted or mutated giving rise to neoplastic phenotypes. Chemotheraphy is presently used in three main clinical settings: Adjuvant treatment to surgery or radiation therapy or both. Neoadjuvant tx for patients w/ localized disease where surgery, radiation, both are insufficient. Primary induction treatment for advanced disease or cancers w/no other options. First cancer drugs were nt (had no known target; we didn"t care how they worked). As drugs progressed, scientists have become more aware of the targets of medicine. If we can target meds, we can hopefully limit side- effects. Phase 2:might recognize effects in patients w/co- morbidities off-label use. This reflects empirical nature of medicine, we still have to rely on observation to develop treatments.
