INDS 111 Lecture Notes - Lecture 31: Pattern Recognition Receptor, Inflammasome, Lymphangitis

• School: McGill University
• Department: Interndisciplinary Studies
• Course: INDS 111
• Professor: Anne Andermann

Document Summary

Responses to cell injury: inflammation and repair i & ii. Bring circulating wbc and plasma proteins to site through release of chemical mediators. Cardinal signs: heat (calor), redness (rubor), swelling (tumor), pain (dolor), loss of function. Normally self-controlled & limited, but: can cause it"s own damage if strong, prolonged, Recognition of problem: by pattern recognition receptors designed to detect presence of microbes and/or substances released by dead cells inappropriate. Inflammasome: cytoplasmic complex, recognizes dead cells and some microbial products. Inflammasome activates enzyme (caspase-1) that cleaves cytokine il-1b into active form leukocyte recruitment: also activated by: urate crystals (gout), cholesterol crystals and ffa (atherosclerosis), so blocking il-1 is a possible treatment target for these diseases. Increased flow secondary to vasodilation: arteriolar vasodilation increased flow, engorgement of down-stream capillaries (heat, redness, also causes increased permeability exudate (high protein, wbc and rbc) enter ct, viscosity increases small vessels packed with rbc (stasis) Stasis wbc (mostly neutrophil) margination as wbc pushed aside" by.