PHAR 300 Lecture Notes - Lecture 5: Classical Conditioning, Homeostasis, Amygdala
14 Oct 2015
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Dosing schedules: half-life is determined by how well you can metabolize the drug, drug is given orally/intravenously - want to keep drug concentration between minimum effectiveness and maximum safety. Sept. 22, 2015: helps decide how many doses at what concentration to give o. If a drug is given at every half-life, there will be a steady state after ~4 doses: a loading dose could be given if an effect is needed right away. Biological adaptation to drugs: tolerance, addiction, dependence, withdrawal. Tolerance: chapters 27 and 37, no longer respond to a drug and/or need higher doses to get the same effect, how to study tolerance, studying in animal models, e. g. rat. A rat can push a lever that will give it an intravenous dose of the drug. Some drugs, they will never inject, but other drugs, the rat will inject over and over again: study on humans.
