BIOLOGY 2B03 Lecture Notes - Lecture 10: Adult Stem Cell, Cyclin D, G1 Phase
23 Apr 2020
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Module 10 lecture 2: cell cycle dynamics and checkpoints: checkpoints that maintain cell. Integrity: will eventually undergo regulated cell death or apoptosis. E2f c-fos: c-fos is an early response gene, tcf and srf don"t need to be translated, just phosphorylated, c-fos needs to be translated. Apc inactive = cell stays in metaphase: closed conformation of cdc20 passed from one cdc20 to another, closed cdc20 + open cdc20 = closed cdc"s protein information gets transferred. Sac is passed: mad1 + mad2 proteins released from kinetochore after bipolar attachment to mitotic spindles, p31 binding to closed conformation of mad2 causes complex to go away from chromosomes and promotes change in. ****mad2 open doesn"t bind to cdc20, only closed. Mitotic exit network (men: events associated with exit from mitosis include reassembly of nuclear envelope, chromosome decondensation, reassembly of mitochondrial, golgi and. Mpf: dephosphorylation of cdh1 requires cdc14 (a phosphatase, key step in men = activate cdc14.
