HTHSCI 1DT3 Lecture 16: 1.3 Cells.19
23 Jun 2018
School
Department
Course
Professor
Molecular diagnostics of gliomas: state of the art
Markus !J
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!Riemenschneider !• !Ju d ith !W. !M. !Je uken !•
Pieter !Wesseling !• !Guido !Reifenberger
Received:Acta Neuropathol (2010) 120:567–584
Molecular classification of gliomas
GBM (Glioblastoma Multiforme):
WHO Grade IV astrocytoma (most biologically aggressive glioma subtype)
90% of GBMs arise de novo (primary GBM) while 10% arise from a lower-grade tumour
Outcome of patients with GBM is still poor (12-18months post surgery)
However, GBM is highly proliferative, infiltrative cancer.
Impossible to completely resect.
Most chemotherapeutic agents do not efficiently get into the BBB.
Less common than most solid tumours, so limited research.
Current Treatment Approaches
Surgery
Radiotherapy (high dose) over 6 weeks +/- TMZ (25% alive over 2 years)
Radiotherapy (low dose) over 2 weeks (months)
Gliadel wafers
Best supportive care
Genetic Alterations in Glioblastoma frequently affect signalling
pathways
RTK/PI3K/Akt – EGFR, PDGFR
VEGFR
Cancer 2011, 3, 324-327
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