HTHSCI 1DT3 Lecture Notes - Lecture 11: Ccl11, Model Organism, Chronic Obstructive Pulmonary Disease
13 Aug 2020
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Mod. 2-5 cytokines, chemokines and their receptors 4. Ting joe li yah: rantes binds to three receptors ccr1, ccr3 and ccr5 important in asthma. Targeting that chemokine can possibly target all other cells involved: ccl11 (eotaxin) binds to ccr3 and ccr5. This cause the chemotaxis of eosinophils (hallmark of asthma) Eotaxin binds with high affinity to ccr3 because low concentration of eotaxin is needed. Eotaxin does not really work through ccr5: chemokine receptor redundancy assumption. Different chemokines are equipotent at single receptor (but not true as one chemokine will have stronger affinity for one receptor) Different chemokines have the same function at a single receptor. Cxcr2 that is present on both cells: neutrophils are innate response and get to the site of infection quick and fast. Ltb4 (does not cause bronchoconstriction) and fmlp (breakdown product of bacteria cell wall) are neutrophils chemoattractant. Cxcr2: no degranulation and a lot of migration (chemotaxis)
