HTHSCI 1H06 Lecture Notes - Lecture 6: Posterior Pituitary, Vasodilation, Anaphylaxis
27 Jul 2018
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Describe the causes and classification of shock. Discuss the homeostatic mechanisms employed in response to shock. Discuss examples of shock in each class using a case study approach. Cv system fails to perfuse cells, tissues and organs. Results in widespread impairment of cellular metabolism and tissue function. Characterized by decreased oxygen delivery + increased demand for oxygen (cid:3203) cardiogenic, hypovolemic, obstructive, and distributive (cid:3203) cells become damaged if perfusion is not restored and death may occur. What determines o2 delivery: blood pressure = co x svr, systemic vascular resistance = (viscosity x length)/radius4, cardiac output = sv x hr, stroke volume = preload, afterload, contractility, oxygen content = partial pressure of oxygen. Preload: amount of filling of the ventricle during diastole (cid:3203) as the heart fills more, it stretches slightly (cid:3203) stretching of the myocardium stimulates it to contact more forcefully = increase in.
