HTHSCI 1LL3 Lecture Notes - Lecture 6: Histidine, Drug Metabolism, Cunt
22 Jun 2018
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ENZYMES
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Enzymes
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(deft proteins that make chemical reactions go faster or start (catalyze reactions )
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named by adding suffix "
ase "
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eg .lactate ,deoxy hydrogenate ,carboxyl use ,polymerase ,transfer ate
Catalytic Action of Enzymes
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Enzymes increase the rate of chemical reactions and are specific for one reaction depending on the amino acids making up the enzyme
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In an absence of an enzyme ,you only get 100 golf balls 1year of a total of 380000
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with an enzyme ,all 380 000 are obtained within Isecond
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they arent permanently changed in these reactions
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They bind to substrates and release the products once the reaction is complete
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substrate !substances that are reaching
Steps in an Enzyme -Catalyzed Reaction
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Binding of the substrate :Et so ES
2Conversion of substrate to product :ES←Ep
3Release of product :Epa Etp
by forming additional bonds
Transition state Complex
Transition state
initial
final
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Mechanism of Action
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Enzymes lower activation energy so more molecules can enter the transition state and proceed to products .
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.Trate of reaction
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activation energy : amount of energy required to go from reactants to products
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Dont change reactants or products
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Shape or conformation brings the substrates together so that the reaction can proceed
•The active site is dependent on the amino acids that are located there
Document Summary
Enzymes ( deft proteins that make chemical reactions faster or start ( catalyze reactions ) go named by adding suffix ase i eg . lactate , deoxy hydrogenate , carboxyl use. Enzymes increase the rate of chemical reactions and are specific for one reaction depending on the amino acids making up the enzyme. 100 golf balls 1 year of a total of. I second they arent permanently changed in these reactions. They bind to substrates and release the products once the reaction is complete substrate ! substances that are reaching. Binding of the substrate : et so es. Conversion of substrate to product : e s ep. Enzymes lower activation energy so more molecules can enter the transition state and proceed to products . i. T rate of reaction activation energy : amount of energy required to go from reactants to products. Shape or conformation brings the substrates together so that the reaction can.
