HTHSCI 2H03 Lecture 3: Development of the Dosage Regimen
18 Sep 2018
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Document Summary
The onset, peak and duration of drug actions. Intensity of drug action (amount of drug absorbed & distributed) Duration of drug action (rate of drug metabolism & elimination) Slower metabolism - means drug acts for longer. Fraction of administered dose that reaches the plasma (systemic circulation) in a chemica active form. Orally administered drugs have losses - enters hepatic circulation first - reduc. Distribution mically unchanged and biologically reduces overall bioavailability. Process by which a drug reversibly leaves the blood stream and enters body tissues. Impacted by blood flow, solubility of the drug, organ size, etc Think about the human body as a beaker. Ratio of the amount of drug in the body to the drug concentration in the plasma. Every drug has a different value for this. The volume into which a drug is known to distribute within the body. Keep the weight in mind for pediatrics to make sure we"re dosing our patient.
