HTHSCI 2H03 Lecture Notes - Lecture 15: Multiple Endocrine Neoplasia, Neurotransmitter, Biguanide
29 Apr 2016
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May or may not have any symptoms; r/t complication. Type of insulin - depends on insulin delivery system. Inhaled insulin - not yet commercially available. Mimic endogenous insulin secretion; basal and bolus. Basal = background" insulin that addresses hepatic glucose production. Bolus = secreted in response to energy. Used to be basal (cloudy) bolus (clear) Basal-bolus (prandial) insulin regimens (mdi) or csii are best insulin regimens for t1dm. Insulin regimens should be tailored to the individual. All individuals with t1dm should be counseled about the risk, prevention and treatment of hypoglycemia. Three basic metabolic defects characterize the disease: An insulin secretory defect that is not autoimmune-medicated. An increase in glucose production by the liver. Combination therapy -- address multiple pathophysiological defects. Many different classes of drugs for t2dm. Ef cacy of a drug = low a1c. Effect on weight and other side effects.
