HTHSCI 3BB3 Lecture Notes - Lecture 4: Biopsy, Birth Weight, Osteoporosis
3 Oct 2016
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Document Summary
A disease of the small intestine characterized by an abnormal mucosa and associated with permanent intolerance to gluten in genetically susceptible individuals (hla-dq2/8). Exclusion of gluten from the diet results in clinical remission and normalization of the mucosa. You have to have a particular genetic make-up in order to be diagnosed with celiac disease. Dq2/8 is a necessity to be diagnosed with celiac but not everyone with this marker will have celiac. It requires three main factors: genetics (hla-dq2/8), autoantigen (tissue transglutaminase), and an environmental trigger (gluten). Gluten is a protein found within grains such as wheat, rye and barley. There is an autoantigen that arrives when you have that environmental trigger. There is a component of the gluten called gliatine. The trigger is usually something that makes the gut leakier so that protein can get across and be recognized by the immune system.
