NURSING 2LA2 Lecture Notes - Lecture 5: Bronchial Hyperresponsiveness, Muscle Hypertrophy, Mast Cell
18 Feb 2018
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Document Summary
Hyperplasia: increase in cell population lge: antibody that triggers histamine release in mast cells leukocytes: white blood cells, involved in the late phase of asthma leukotriene: slow, prolonged bronchoconstriction, vasodilation, and vascular permeability (long acting histamine) Canadians >12 y. o. (statistics canada: 2,448,817 (2014, 2,363,010 (2013, 2,511,890 (2011) -> peak year, 2,362,902 (2008, 2,249,703 (2005) Childhood asthma rates highest in atlantic provinces, lowest in british columbia and. Prairie provinces: off-reserve aboriginal people 12 years old and older is higher than that of the general population. Rates are steadily increasing around the world: significant increase in children aged 5 and younger and children 10-11. Despite the increase in asthma prevalence, asthma attacks have decreased from 51%-39% between 1994-1995: 60% in women aged 35-44 years, 80% increase in women aged 45-64, 41% increase in women 35-44 years. Susceptibility is determined during fetal development and the first 3-5 years of life. Il-4, il-5, il13: interleukins- group of cytokines (signal molecules) expressed by leukocytes (wbc)
