NURSING 3PA2 Lecture Notes - Lecture 2: Aureus, Antibody, Sepsis
Document Summary
The purpose of this review article is to review previous literature on toxic shock syndrome (tss), its pathophysiology, symptoms and treatments. As well, to update and educate health care practitioners on recent findings regarding the pathophysiology of tss, for better patient outcomes. Toxic shock syndrome (tss) is an acute, life-threatening illness usually caused by the colonization of staphylococcus aureus and overwhelming t-cell activation, resulting in multiple organ dysfunction and quickly progressing shock. Tss toxin-1 (tsst-1) is a toxin produced from tss, and is responsible for exacerbating the immune response, and contributing to the multiorgan failure associated with tss. Incidence rates have declined since the 1980s; 12 per 100,000, with recent evidence suggesting a tss incidence rate of 2. 1 per 100,000. Diagnosis for tss is difficult to detect, due to similarities with other types of shock. Indications of tss include: rapid onset of fever, rash, desquamation, hypotension, and multiorgan failure, without the presence of an obvious infection.