PSYCH 2NF3 Lecture Notes - Lecture 2: Neuroglia, Biomarker, Oligodendrocyte
3 Apr 2018
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2: intra-cortical mr signal as a biomarker for pathology. Scales of neuroscience: macro-scale: cm, meso-scale: millimeters, micro-scale: micro and nanometers. Brain anatomy: white matter: highway for information to travel throughout brain, grey matter: where processing of info is happening. The changing brain: the brain is always hanging either due to adaptation or disease, axons can sprout, changes in the dendrites, size of glial cells, changes in amount of myelin. Increase or decrease in number of neurons in brain. Image intensity is describing the underlying tissue composition: measuring signal, signal in certain imaging protocols is spatially correlated with myelin, can provide insight to myelin density. T1 weighted imaging: signal analysis requires removal of bias fields need to correct for shading, we used a ratio of t1 w/pd image known to report myelin content. Healthy aging: how doe the cortex change with healthy aging through middle adulthood, myelin should increase into middle-adulthood, then taper off.
