BIOL 3530 Lecture 10: Chapter 8
7 Oct 2016
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Document Summary
Microarray analysis can be utilized to study differences in gene expression. The earliest stage of cell differentiation is cell determination where the cells becomes committed to a subset of cell fates. The reversibility and inheritance of patterns of gene activity. Two possibilites are: loss of genetic material, regulatory proteins (transcription factors, chromatin proteins?) Transgenic studies have revealed much about gene activity and differentiation. Control of transcription involves both general and tissue-specific regulators of transcription. First, the rna polymerase binds to the start site of transcription in the promoter. Then the dna is unwound so that the template dna can be copied. The control regions of a gene contribute to the ability of the rna polymerase and associated proteins to start transcription. Cooperation of general transcription factors and rna polymerase ii is required to bind to the tata box of the promoter. The enhancer elements bind regulatory proteins (transcription factors).
