NURS 2004 Lecture Notes - Lecture 5: Headache, Bile Acid, Stomach Cancer
26 Jan 2017
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Document Summary
Peptic ulcer disease (pud) refers to a group of upper gastrointestinal (gi) disorders characterized by varying degrees of erosion of the gut wall. Ulceration most common in the lesser curvature of the stomach and duodenum. Peptic ulcers develop when any region is exposed to acid"s pepsin and are most common in lesser curvature of stomach and in duodenum. Develop when an imbalance exists between mucosal defensive factors and aggressive factors. Abdominal pain after a meal- usually 2-3 hours later. When defensive factors are intact, makes ulcers unlikely. 1 mucous- secreted by cells of the gi mucosa, forms a barrier to protect underlying cells from acid and pepsin. 2 bicarbonate- secreted by epithelial cells of stomach and duodenum, trapped in the mucosal layer, it neutralizes hydrogen (h+) ions that penetrate it. 3 blood flow- good flow maintains mucosal integrity, decreased blood flow means increased risk of ischemia, cell injury and attack by acid and pepsin.
