PSYC 2800 Lecture Notes - Lecture 8: Gaba Receptor Antagonist, Raphe Nuclei, Autonomic Nervous System
18 Dec 2016
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Document Summary
Acetylcholine esterase is the enzyme present within the synaptic cleft that hydrolyses acetylcholine to choline and acetic acid. Binding of acetylcholine to its receptor opens a na+ channel, depolarizing the membrane. May lay a role in initiation of food intake (appetite: serotonin. Found in the brain stem raphe nuclei. May have a role in impulsivity, aggression, depression, control of food, and alcohol intake. Hallucinogenic drugs such as lsd influence serotonin pathways. The diet drug sibutramine causes weight loss by blocking the reuptake of serotonin and norepinephrine. Found is most regions of the brain. Etomidate is a short acting anesthetic and sedative (not analgesic) Metrazol is a gaba antagonist causing seizures. Binding of gaba to its receptors opens a chloride channel, hyperpolarizing the membrane: glutamate. Found in most regions of the brain. Connection between glutamate receptors in brain and euphoric effects of cocaine. Opioid-like chemical occurring naturally in the brain; also referred to as endogenous morphine.
