NEURO410 Lecture Notes - Lecture 14: Neurofibrillary Tangle, Amyloid Precursor Protein, Thioflavin

• School: University of Alberta
• Department: Neuroscience and Mental Health Institute
• Course: NEURO410
• Professor: Dr.Kar

Document Summary

Lecture 3: ad: basic aspects (march 1 /16) Global and progressive deterioration; above = definition of dementia. Definition: age-dependent (most cases) global deterioration of intellectual and cognitive fxn. Symptoms: impairment of memory and attention, language and communication, abstract thinking, judgement, personality changes, depression, and visuo-spatial disorientation. Signs: motor and gait disturbance, extrapyramidal signs, lack of bladder/bowel control, seizures. Extrapyramidal signs: poverty of movement and stiffness (bit like pd) History of symptoms (usually from family or caregiver) and an examination. Tests to e(cid:454)(cid:272)lude other (cid:272)auses of de(cid:373)e(cid:374)tia: (cid:374)europs(cid:455)(cid:272)hologi(cid:272)al tests, (cid:271)lood (cid:449)ork . New tests of brain structure and fxn: mri diffusion tensor imaging to look for disruption of brain connections, pet scans looking for decreased metabolism in the brain, detection of amyloid burden in the brain. 7-9% of canadian population over 65 and 35. 5% of population over 85 have ad* 4. 5 million people in us and canada have ad; by 2050 14 million.