BIOL 205 Lecture Notes - Lecture 23: Essent, Cytosol, Chief Operating Officer
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The sequence below represents the part of the sequence of the sense strand of CFTR (also called coding or non-template strand). Various features of this sequence are indicated on the sequence as well (+1, AUG, introns, stop codon, polyA signal, location of mutations).
Note: this is a fictional sequence that is different from previous semestersâ versions.
CTGAGAAGC....... Transcribed sequence (in red type) AATTAAGAT...... Un-transcribed sequence (in black type)GCCAACTTC........ intron sequence
The mark the identified mutations
The mark the start and stop codon and polyA signal +1 the start of the transcribed area
Part of the CFTR gene sequence (sense strand) NOTE â print / view this page in color!
5â GATGCCGTGCTCCAGGCACAATCTCTTCCAGAACTCGAAACCAACTG AATGGAGTGATCTCGATCAAGCCGGAGCTTCTCTTAACTTCGATTTCGAC GTGAAGAACTTACTTTGATTGCCACATTGGCCCAATTGAAGGGTTATAAT CTCGCTGGGCATTTTGCTCGAATTGCAGTTTAGTTAATTTCGCTTCTTTC TCAGTAAATAATAACTGTGCATCGAAGGCCAACTGGAGATGGAAGTGGAA GTCATTAATATCGATATACAAGAAGTACAATACAACAGTAAGTTATTACC TATTTTTCTTTACTAATCTTTATGATTTATTTAATGTTATTGGACTTATA GAAAATACTTAGAATTAAGATTTGATCCATTTTTTTTTTAAATATTTAGG TTCAAATAAATTAGCCATAGTTATATATTTTTTATGTTTTCATTTACATA AAACATTAACTGTTATTTTTTTAAATTTAAAGGACTAGCTTTTTCAATTG TACAGCACACCCTGTGGCTGCGAGTAACGGTTCTCGGGAGTCGTTATTTT (black)
+1 CTGAGAAGCGCGCAACGTGCACACTGGCAGGCTGATTGAAAAAA5T0TCGTT GCAAATGTTTATGTACAAATATTGAATAAAAAATAAAAATGCTGCGGCAG GAGAACTTGGCA (red)
GCCAACTTCTGCGGTCTCCTGGCCAGCCAGGGCTATCC AGGTGAGTTCGTATTTCGCCAATTTACTCCGAGCCTCATGGATGTCCGTA AAAATCGCAGAG
AAGGCAAACGAGTGGCGCATCTAGTGCCAGGAACAGGA
TGGATCTCTGCTCACGTCCTCGATATTCGAGTACGCGGACGAGGATCAGC GCTAGGAGACGTGCATTGGCCACTTTCACGCCACCCGGACGCAGCTGCGA CTCCTTTGGACCCTCGACAATTGCCGTGAGATCGTCCAGGCAACGATTAA (red)
CAGCAGTGTCACATTGCTGTCCTTCGTGGAGAAAACTGAGGGCAAGCTCT ATCAGGCCTTTGTCGTGGAGGTAAGGAGCTCCGAAGGTGGCACGGCCACG CCCCTCAACTCGGAGCCCTCCAACCGCCAGATGATGACGCAGTTCCTGTG
AATC...(black)
ATG
green boxes
magenta boxes
Mutation 1
AGAACTC
Deleted bases in some patients
Mutation 2
C changed to T in some patients
Mutation 3 |
Mutation 4 |
6
GCGCGTCGAGAGTGCCACGCGCACCTGCTGGCAGGACAAGCTACTGGTGC TCACCCACGAGGAATGTAGGTGTCATGTATATGTCATTATCCACCTCTAACTCCCATGCTCGTACCTGTTTTTTCTAGCCATCAAGCAGTACAGCTGCGT GGTCAAGCAGAGCTCCACCACATGCTCGACTGGCGGAGGCGAGGGCAGCG CCTGGAGGCTAGACACCAGCATACTGACCTACGAAACGCTGGCCAGGAAC TTTAGCTGGGCCCAGTGGGATCCCGAGTGCCAGGCTCTTTATTACATTCA CTTGAAGCCGAAGGCCAAGAGCCTCAGTCTGCTGGACGAGAGGGAGGAGG TTTAACAATAAACAGCCAACGGAAACAGTGGTAGGTACTTAAAGATTAAATGACTGTGCGTTAGGTCCTGTTCATTGGTACCCTTTATGAGTTAATTCAA ACCCACGGACATGCTAAGGGTTAATAAACAATCATATCGCTGTCTC 3â
1. For each of the 4 mutations identified on the previous page, answer the following:
a. Where is the mutation relative to the CFTR gene? (e.g.: un-untranscribed region, 5â UTR, 3âUTR, intron, exon)