CMMB 403 Lecture Notes - Lecture 10: Paraxial Mesoderm, Intermediate Mesoderm, Sox9
30 Sep 2018
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Transloaction of sry gene to another chromosome. Remarkably tenuous balance determines ovaries versus testes in the developing gonads. Sex reversal: chromosomal complement that should develop as one sex, but develop as the other. Sry is a gene found on the y chromosome. Xy people lose this gene that allows for the sex reversal, so they become female. If there is a translocation of this gene to another chromosome, xx become male. Expressed in supporting cell of the gonad (stem cell) somatic cell. Germ cells develop in close association with these somatic cells. Sry activates sox9, which supports sertoli cells which allow the gonad to develop as a testes. Sry activates rspo1, which activates wnt4, which causes the granulosa cells to form eggs, and causes gonads to develop into ovaries. 4 main categories of mesoderm: gonads form from the intermediate mesoderm. From midline (medial to lateral) of the body of the embryo is the chorda-mesoderm (develops into notochord)
