CMMB 403 Lecture Notes - Lecture 10: Intermediate Mesoderm, Sox9, Granulosa Cell

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People with sex reversals are sterile, and only find out they have this condition when they visit a doctor for fertility issues. Xy people lose this gene that allows for the sex reversal (thus, become female) If there is a translocation of this gene to another chromosome, xx become male. Expressed in supporting cells of the gonads (stem cells) somatic cells. Germ cells develop in close association with these somatic cells. Sry activates sox9, which supports sertoli cells which allow the gone to develop as a testes. Sry activates rspo1, which activates wnt4, which causes granulosa cells to form eggs, and causes gonads to develop into ovaries. From midline (medial to lateral) of the body of the embryo is the chorda-mesoderm (notochord) Is a bit lateral, and forms a column (sausage-like tissue) extending from the mid part of the embryo.

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