CMMB 403 Lecture 36: Bones and Muscles — Part 2
7 Jan 2019
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Preypertrophic chondrocytes became hyper meaning they grow in size. Prehypertrophic makes ihh, which represses expression of twist (normally it represses activity of runx2) Repressing a repressor, which means you"re turning something on. Cells that express runx2 activate osteric, which allows prechondrial cells to become osteoblast. Without runx2, get no osteoblasts, so no bone forms. True for intramembranous region as well, it wont form bone. All skeletal muscles are made from myotome of somites. Cells at the lateral lip of myotome become migratory and migrate around the body to form muscles. They start to differentiate when they are migrating. To form muscles, these cells are determined by either of two or both of the tfs: myf5 or. If you knock out both tfs, you don"t get any muscle. Cells of medial myotome form back muscles. Lip of myotome towards the neural tube. From medial lip towards the neural tube, cells form back muscles.
