CMMB 411 Lecture Notes - Lecture 31: Regulatory Sequence, Alternative Splicing, Polyadenylation
19 Dec 2018
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Document Summary
Transcription initiation is the primary point of gene regulation, but there is regulation at all steps of rna synthesis and processing. Transcription factors often act combinatorially and synergistically, with multiple activators controlling transcription of a given gene. Chromatin structure has a profound influence on gene expression. Alternative splicing is important in many eukaryotes. Depending on what factors are present, you can get many different transcriptional properties of genes. Combinatorial: factors work in combination in some way. Different factors work in combination, so that they act individually. Very general term, meaning that you have multiple factors working together in some way. Synergistic: the effect of factors is greater than the sum of the parts. Parts that work together and the effect of the different parts is more than the sum of the different parts. Transcription factor: any molecule (eg. protein) that is involved in transcription and is not part of the polymerase.
