CMMB 431 Lecture Notes - Lecture 7: Airway Obstruction, Pseudomonas, Bronchiectasis
25 Jun 2020
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Clinical seminar: chronic lung infections in cystic brosis. Median life expectancy of cf patients in canada is 51 years. Survival in canada is better than the uk: true. Liver disease is the third leading cause of death in individuals with cf. Cf is a disease of chloride transport. There is altered transport at epithelial surfaces, in lungs, it results in mucus layers becoming thick. Despite cf being in the airways things in mucous are relatively anoxic. Defective cf gene > defective/de cient cftr > abnormal airway surface environment. Don"t look for inspiratory capacity, what matters is expiratory capacity. Elasticity of the lungs gets the air out, because of cf the elasticity degrades, so air release is slow. Prevalence of organisms in cf airways changes over years. In children see high rates of methicillin susceptible s. aureus. P. aeruginosa worsens clinical progression in cf. As people age, they will be exposed to pseudomonas in the natural environment.
