CMMB 461 Lecture Notes - Lecture 8: Dna Microarray, Transcriptome, Blood Test
30 Sep 2018
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A transcriptome is defined as a complete set of transcripts encoded in the genome and their relative levels of expression in a particular cell or tissue type under defined conditions. Essentially, it is knowing all the sets, or species, of rna there are. This knowledge is needed to understand how living things work. Knowing about the transcriptome can help use learn about how different environmental conditions affect gene expression. In a heat shock condition, you should know that chaperone protein concentrations rise. A lot of dna repair genes concentrations go up hen you expose the cell to a substance. Dna is being destroyed, so cells respond by trying to out the effects of the thing attacking the cell. Genes aberrantly expressed in cell and tissue disease (molecular basis behind the disease) Genes expressed in response to environmental toxins and pharmaceutical compounds (mode of actions and side effects) Genes expressed in response to pathogens (mode of infection and virulence)
