BIOC 3560 Lecture 1: Biochem PACK ONE.pdf
3 Dec 2014
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Academic integrity is required to take this course. Academic misconduct limits learning and disadvantages honest students. For university policy on academic misconduct and penalties see: http://www. uoguelph. ca/registrar/calendars/undergraduate/current/c08. For a better understanding of academic integrity see tutorials at: http://www. academicintegrity. uoguelph. ca/ http://www. academicintegrity. uoguelph. ca/plagiarism. cfm. Grade assessment: midterm exam: 40% day, oct , :pm. Reversible modulation of protein function: proteins are dynamic molecules, function is influenced by interactions with other molecules interactions can be very stable . Prosthetic group: a compound/cofactor that is permanently associated with a protein and required for its function. Or interactions can be transient and short-lived. Protein-ligand interactions ligand: a molecule that is bound reversibly binding site: position on a protein that interacts with a ligand by a protein. Hydrophobic/hydrophilic properties: complementary in, interaction is highly specific, proteins can have > 1 binding site. Binding of the enzyme dihydrofolate reductase to its substrates demonstrates the complementary shapes of ligand and ligand- binding sites in a protein.
