BIOL 1080 Lecture Notes - Lecture 22: Sarcopenia, Calorie Restriction, Dementia
Document Summary
Ti(cid:373)e fro(cid:373) o(cid:374)set of sig(cid:374)ifi(cid:272)a(cid:374)t memory impairment to death in ad is about 7-15 years. Slide 3a: shows a 25-year-old brain vs. a 75-year-old brain with sarcopenia, ar(cid:272)ope(cid:374)ia: (cid:373)us(cid:272)le tur(cid:374)ed to fat. (cid:862)(cid:373)us(cid:272)le (cid:449)asted (cid:272)o(cid:374)ditio(cid:374) (cid:449)ith fat i(cid:374)filtratio(cid:374) (cid:272)o(cid:374)ditio(cid:374)(cid:863) Slide 3b: sarcopenia is part of the frailty syndrome. Slide 4a: e(cid:272)o(cid:374)d theory: (cid:862)its i(cid:374) our ge(cid:374)es(cid:863) theory. Longevity project where they study genetic engineering & longevity drugs (governments do not want to fund projects like these) Slide 5a: mitochondrial theories of aging: old theory & many new twists, dna polymerase gamma: will replicate and repair mitochondrial dna. Last theory: (cid:862)rate of li(cid:448)i(cid:374)g theory(cid:863: nutrition, exercise & sleep impact this theory. Slide 6a: caloric restriction can optimize the healthy lifespan but at the risk of decreasing reproductive success, reproduction shows evolutionary driving force, species eat a certain amount because of optimal reproduction. Increase in calorie intake above normal range for a certain species, actually decreases reproduction (obesity)
