BIOL 1080 Lecture Notes - Lecture 14: Single-Nucleotide Polymorphism, Reactive Oxygen Species, Polg
Document Summary
Bio lecture #14 lifestyle, aging & disease. Related to damage & mutations in mitochondrial dna (much more susceptible to damage than cytosol or nucleus bc of free radical formation etc) 10 million snps in human pop. , 1 every 300 nucleotides. Most frequent source for polymorphic changes (genetic variation!!!!!) Example: aging = assoc w increase in pro-infamm cytokines, which contributets to various age-re- lated disorders (alzheimer"s, cvd, arthritis) Interleukin-6 (il-6) = a pro-inflamm cytokine (plasma levels positively correlated w greater mortality) a snp in the promoter region for il-6 can increase il-6 and is associated with greater mortality. With aging, dna polymerase gamma corrects errors less effectively. Pol-g (polymerase gamma) mice carry mutations in poly-g. replication (catalytic activity) maintained, but not proof-reading activity. Mice show accelerated signs of aging evident by 25 wks (young adult stage) --- weight loss, hair loss, curvature of spine.
