BIOL 1090 Lecture Notes - Lecture 19: Leucine, Autophagosome, Tethering
12 Oct 2016
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Like paintballs: volvox, they have contents inside, they can burst. Macromolecule transport within cells, between cells, out of cells. Question: coated vesicles may be covered by all of the following except: Amino acid sequence that directs protein back to er = er retrieval signal. Soluble/luminal er proteins contain kdel (lysine-aspartic acid-glutamic acid- Kdel receptors in membranes of cgn and cis golgi bind to retrieval signal of. Kdel receptors bind to copi complex proteins and are incorporated into copi vesicles. Escaped proteins reach the er in (copi-coated) retrograde transport vesicles. Trafficking vesicles to a particular compartment: movement of vesicle. Uses cytoskeleton and motor proteins: tethering vesicle to target compartment. Uses proteins called rabs: docking of vesicle to target compartment. Uses proteins called snares: fusion of vesicle and target membrane. Vesicles being rushed around the cytoskeletal filament: vesicle membrane is becoming fused with the membrane. Clathrin-coated vesicles move from tgn (trans-golgi network) to other vesicles (eg:
