BIOL 1090 Lecture Notes - Lecture 12: Neurofibrillary Tangle, Tau Protein, Intermediate Filament

• School: University of Guelph
• Department: Biology
• Course: BIOL 1090
• Professor: Jaideep Mathur

Document Summary

Biol 1090 week 12: cytoskeleton: a dynamic network of protein filaments that forms the cellular scaffolding as well as transport system for organelles and vesicles (slightly rigid to still allow for movement) 3 major elements: microtubules: hollow, unbranched tubules of tubulin monomers; outer diameter of ~25 nm; found in all eukaryotes. Intermediate filaments: fibrous, various proteins; diameter of 10-12 nm; form between microtubules and microfilaments; like a rope tough; not found in plant cells: microfilaments: solid, thin, branched, actin polymers; diameter ~ 8 nm; found in all eukaryotes. Cytoskeleton functions: structure and support, intracellular transport, contractility and motility ability to move around (what differs in animals vs. plants/ fungi, spatial organization. Classes of maps: motor maps: two types kinesin and dynein, use atp to generate force (cid:272)a(cid:374) (cid:373)o(cid:448)e (cid:373)aterial alo(cid:374)g mt (cid:858)tra(cid:272)k(cid:859) can generate sliding force between mts, non-motor maps: control mt organization in cytosol (ex. Tau protein in neurons: defe(cid:272)ti(cid:448)e tau protei(cid:374) (cid:373)ea(cid:374)s (cid:374)eurofi(cid:271)rillary ta(cid:374)gles = alzhei(cid:373)er(cid:859)s.