BIOL 1090 Lecture Notes - Lecture 10: Nuclear Lamina, Nuclear Membrane, Nuclear Pore

• School: University of Guelph
• Department: Biology
• Course: BIOL 1090
• Professor: Jaideep Mathur

Document Summary

Characteristics: 5-10% of cell volume: not a xed number, about 10 um diameter, typically one/cell. Functions: storage, replication and repair of genetic material, expression of genetic material, ribosome biosynthesis: dna storage to protein synthesis. Structure: nuclear envelope, nuclear membrane, nuclear lamina, nuclear pores (4000-5000, nuclear content, chromatin, nucleoplasm, nuclear matrix, nucleolus. The nuclear lamina: structure, this meshwork of laments, lamins (type of intermediate lament, approx. 10nm diameter: integrity regulated by phosphorylation, bound to inner surface of nuclear envelope, function, support structure for nuclear envelope, attachment site for chromatin. Lamin a causing nuclear envelope to collapse make children look old = progeria: point mutation of cytosine to thymine. 120 nm diameter: gateways between cytoplasm and nucleoplasm, 3000-4000 pores/nucleus, facilitate nuclei-cytoplasmic transport. Nups = nuclear porins = proteins found in the pores, decide what size molecules can come in or go out of nucleus. Protein structure lls nuclear pore: supramolecular complex, 1. 25x10^4 kda, 100"s of polypeptides cytoplasmic.