BIOL 1090 Lecture Notes - Lecture 8: Plasmalogen, Microbody, Endoplasmic Reticulum
28 Jul 2019
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Review: transport vesicles: move proteins between compartments or to plasma membrane, er: compartment flattened sacs, tubules, rough er: ribosomes on cytoplasmic membrane side, site of cotranslational import, smooth er: no ribosomes, protein sequence info determines proteins" destination. Protein trafficking, mislocalization in disease: peroxisome: microbody organelle. Found in all eukaryotic cells, enzymatic rxns. Catabolism of long fatty acids, reducing ros, plasmalogens synthesis: zellweger syndrome: autosomal recessive. Brain defects, hypomyelination, apnea, abnormal renal function, < 1 yr. Abnormal: cystic fibrosis: cftr mutation, 3 nucleotides deleted, loss of phenylalanine. Proteins targeted to mitochondria & chloroplasts: n-terminal/signal sequence direct proteins to organelles, at organelle, other intrinsic sequences direct to membrane, mitochondria: omm, imm, intermembrane, matrix, chloroplast: ocm, icm, thylakoid membrane/lumen, stroma, proteins made completely in cytoplasm first. Er golgi: golgi apparatus receives proteins/lipids, sorts them (other organelles, plasma membrane or exterior, material moves er golgi other (proximal to distal direction, cis-golgi network (cgn) medial-golgi trans-golgi-network (tgn)
