BIOL 1090 Lecture Notes - Lecture 11: Cytokinesis, Nucleoplasm, Phospholipid

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Kinesin and dynein: intermediate filaments (if) are non-polar and provide structural and mechanical support, actin filaments (mfs) are polymers made up of g-actin monomers - they are important for cell shape. 2: which of the following cytoskeletal structural components do not have polarity, f-actin, microtubules, keratin monomer protein, intermediate filaments, kinesin. 3: briefly describe how dynein and kinesin work. Both are motor proteins that use atp as a powers source. They transport vesicles and other cell components along microtubule tracks only. Direction of movement is polarized: dynein (- to +), kinesin (+ to -) Microfilaments (mf: smallest cytoskeletal element (~ 8 nm, polymer of protein actin, polypeptide = 42 kda, binds atp. Polymerized microfilament = f-actin: several well-characterized functions. G-actin dimers trimers short filaments: elongation (fast) Monomers add to both ends: faster at +" end. Filaments can be loose arrays/networks or tight bundles/cables. Examples of actin-binding proteins nucleating proteins; e. g. arp2/3: monomer-polymerizing proteins; e. g. profilin filament-depolymerizing proteins; e. g. cofilin.

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