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Lecture 18

Lecture 18

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BIOL 3010
Scott Schau

Outline of Lecture 18 Kidney Development I. The kidney is designed to filter the blood A) Functions: regulate body fluid osmolarity and volume; electrolyte and acid- base balance; produce EPO B) Gross anatomy (p.1 figure): ureter, hilus, medulla, cortex, nephron C) Nephron structures (p.2 figure): Bowman’s capsule, glomerulus, renal corpuscle, podocytes, basement membrane; ascending and descending limbs, collecting duct II. Kidney development - The intermediate mesoderm gives rise to the pronephros, mesonephros, and metanephros, which develop in that order and each elongate caudally 1) Pronephros: mesenchymal cells from the 10 somite migrate and proliferate to form the pronephric duct, which degenerates and has no mammalian function 2) Mesonephros: forms in the nephrogenic cord; meson. tubules connected by meson. duct, which leads to urogenital sinus; becomes part of male reproductive system 3) Metanephros: develops into adult kidney - ureteric bud from the mesonephric duct invades metanephric mesenchyme and induces nephron formation - mesenchymal condenses to form blastema, which develops into a primitive nephron in a process that involves reciprocal inductions - ureteric branching gives rise to the whole complement of nephrons - blood vessels follow ureteric bud, which allows proper contact at each glomerulus - kidney shifts from pelvic region to abdominal region and contacts adrenal gland III. Genes involved in kidney induction A) Initiation of duct formation - Lim1: txn factor expr by intermediate mesoderm required for duct formation - Pax
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