BIOM 3090 Lecture Notes - Lecture 4: Anticoagulant, Median Toxic Dose, Tachycardia

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3090
• Professor: Bettina Kalisch

Document Summary

The study of pharmacodynamics is based on the concept of drug-receptor binding. When a sufficient number of receptors are bound in the cell then a cellular event can occur. Cumulative cellular responses produce organ and patient responses. A drug-receptor binding model prediction cellular events is needed. *the affinity of the drug is most influenced by changes in the off state. L + r (=proportion of free receptors) lr (=proportion of ligand bound to receptors)". Kon= forward or association rate of equation. Koff= reverse or dissociation rate of the equation. Koff/kon= a constant for each drug receptor combination. Ka= association rate constant; also equal to 1/kd. By law of mass action, the relationship between free and bound receptors can be described as: If r0= total number of receptors, then [r0] = [r]+[lr] Replacing [r] by [r0]-[lr] and rearranging the equation gives you: *[lr]/r0 is equal to the fraction of all available receptors that are ligand bound, so when [l]=