BIOM 3090 Lecture Notes - Lecture 27: Phare, Vastus Lateralis Muscle, Intravenous Therapy

• School: University of Guelph
• Department: Biomedical Sciences
• Course: BIOM 3090
• Professor: Bettina Kalisch

Document Summary

Lecture 3- major physiological receptor families: signal transduction. Physiological receptors have 2 major functions ligand binding via ligand-binding domain (attracts drug), and messenger propagation via the effector domain. Drugs modify cellular function after binding to receptors to initiate, enhance, diminish, or terminate responses. The receptors, cellular targets, and intermediary molecules are collectively part of a. Major types of physiological drug receptors: ion channels. Membrane lipid bilayers are impermeable to polar anions and cations ion channels have roles in neurotransmission, cardiac conduction, muscle contraction, and secretion. Channels can be classified based on architecture (subunits), ions that are conducted through the channel, and mechanism of activation. *ligand and voltage-activated channels are major drug targets. Ligand-activated channels- major ligand channels found in the cns. Excitatory nts (ach/glutamate) and inhibitor nts (glycine or gaba) The nicotinic ach receptor is a ligand-gated channel isoforms are found in skeletal muscle and neurons. Na is the major electrolyte passed; k can also pass.