FARE 1040 Lecture Notes - Lecture 3: Dna Polymerase Iii Holoenzyme, Dna Gyrase, Dna Replication
25 Mar 2020
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Recall: before a cell can divide, each chromosome needs to be copied, 5"= carbon with phosphate, 3"= 3" carbon with oh group. Dna replication: 2 dna molecules are made from 1 dna molecule, 1 new strand and 1 old strand (from the original molecule) will give one double helix or. Dna molecule i. e. semi conservative: the parent dna molecule is identical to its 2 daughter molecules. The process: directionality: replication begins in two directions from the origin as a region of the dna is unwound, dna cannot be completely unwound due to size so replication begins as soon as an opening becomes available. The process: separating the dna strands: replication fork is where the 2 strands are still joined once the strand has been disturbed, replication bubble is when 2 replication forks are close to one another. The process: building the complementary strands: **dna is synthesized in the 5" to 3" direction only!!
