HK 3100 Lecture Notes - Lecture 11: Bone Remodeling, Weight-Bearing, Osteoclast
2 Apr 2018
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Adaptation of bone: highly dynamic tissue which responds to: Internal factors: metabolic, hormonal, nutritional, injury, external factors, mechanical loads, muscle contraction*, adaptation of bone: woolf"s law. "strong muscle makes strong bones: resistance exercise, do(cid:374)(cid:859)t (cid:449)a(cid:374)t to (cid:271)uild (cid:373)us(cid:272)le (cid:271)ut sti(cid:373)ulate (cid:271)o(cid:374)e g(cid:396)o(cid:449)th. If there are any changes the limits can change. But (cid:449)hat a(cid:396)e the (cid:396)isks of p(cid:396)olo(cid:374)ged use of (cid:271)isphospho(cid:374)ates: prolonged use (>4years) increases the risk of atypical fracture, subtrochanteric, transverse, proximal 1/3, minimal trauma/spontaneous, this is due to the fact that the mineralization was changed. Quality versus quantity: affects bone quality by suppressing the natural process of bone remodeling. Impaired repair of skeletal microfractures: altered mineral content, altered material properties. Is more better: short term benefit for sure, but there are natural ways to stimulate bone growth. Is more better: more is typically not better, there is a sweet spot with everything in biology.
