MBG 3050 Lecture Notes - Lecture 13: Y Chromosome, Wild Type, Vas Deferens

• School: University of Guelph
• Department: Molecular Biology and Genetics
• Course: MBG 3050
• Professor: Nina Jones

Document Summary

Sry = sex-determining region y (gene on chromosome y) Tdf = testis-determining factor (protein product of sry) the y chromosome is dominant when sry gene is present it is expressed. Tdf results in testes (male primary sex determination) forming and testosterone production testosterone is responsible for the male secondary sex determination therefore, femaleness is thought to be the default condition, and maleness occurs when sry is present. Mouse 3 shown above is xx and transgenic for sry. It is genetically female but looks male externally. In males:testosterone promotes the development of the wolfkian duct anti-m llerian factor (amf) inhibits the development of the m llerian duct and female reproductive system. In females: estrogen promotes the development of the m llerian duct. Dax1 (a nuclear receptor) may suppress testicular development (??) Sox9 is an autosomal testis-determining gene (vital role in male sexual development) Amf inhibits the development of the female reproductive system males and transgenic female express sox9 and amf above.