MCB 2050 Lecture Notes - Lecture 16: Somatic Evolution In Cancer, Oncogene, Metastasis
22 Feb 2017
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Inherited bilateral retinoblastoma: childhood tumors in both eyes, inherited predisposition, high risk of 2 tumors (osteosarcomas, small deletion of chromosome 13, requires somatic mutation of other allele. Sporadic unilateral retinoblastoma: affects only one eye, no family histor of rb, no further risk of 2 tumors. Rate of appearance of rb tumors was consistent with a single random event for familial tumors and required two random hits sporadic tumors for. Rb acts as a brake on g1 -> s cell cycle progression. Early g1: e2f (a transcription factor) is inactivated by binding to rb, growth factors stimulate signal transduction pathways leading to expression of cyclin. D: cdk4/cyclin d complex hyperphorphorylates rb, which prevents it from binding to. Inherited mutations in the p53 gene associated with li-fraumeni syndrome (rare dominant condition associated with many different types of cancer) P53 protein is a transcription factor that binds dna as a homo-tetramer. P53 protein has a short half-life (ubiquitinated by.
