MCB 2050 Lecture Notes - Lecture 13: Mfn1, Prohibitin, Cardiolipin

• School: University of Guelph
• Department: Molecular and Cellular Biology
• Course: MCB 2050
• Professor: Peter Krell

Document Summary

Evolved from the er: unlikely because mitochondria have two membranes, er has one; mitochondria have own dna, er has none. Endosymbotic relationship: more likely; cells engulf prokaryotes, which transfer genome to our genome mitochondria, this must"ve happened twice in plants because they have mitochondria and chloroplasts. Generation of atp (powerhouse of the cell ) derived from carb and lipid catabolism (tca cycle, oxidative phosphorylation) Contain their own dna (codes for 20-30% of factors involved in their biogenesis & function: organelle biogenesis: included protein targeting, membrane assembly, motility, replication, degradation, & inheritance. Traditionally viewed as individual, bean- shaped organelles, but they actually form a mitochondrial network: highly branched, long interconnected series of tubules, allows for cell-wide coordination of organelle functioning, bean-shape seen during sectioning of a single tubule. Outer membrane: permeable to ions & small molecules, contains porins: barrel-shaped integral membrane proteins with a large internal channel.