MCB 2050 Lecture Notes - Lecture 7: Francis Collins, Human Genome Organisation, Variable Number Tandem Repeat

• School: University of Guelph
• Department: Molecular and Cellular Biology
• Course: MCB 2050
• Professor: Dick Mosser

Document Summary

**genomics** (snustad 7e: ch 15 + 16, pg 431-436) Based on the use of genetic markers (note: genetic markers are not necessarily just genes!) Examples of genetic markers: genes (refer to mbg:2040, snustad chapter 7, rflp (restriction fragment length polymorphism) sites (something that is new, minisatellites (variable number tandem repeats; vntrs, microsatellites (short tandem repeats; strs, single nucleotide polymorphisms: snps. Restriction fragment length polymorphism (rflp) (polymorphism is the occurrence of different forms among the members of a population) Dna polymorphisms: nucleotide sequence variation among individuals within a population, used as genetic markers. Satellite dnas are dnas with repetitive sequences: minisatellites: variable number of tandem repeats (vntrs) of ~10-80 nucleotides (ntds) long, microsatellites: short tandem repeats (strs) of ~2-10 ntd long. This form of dna polymorphism is due to the variable number of the nucleotide sequence repeats (a few repeats to hundreds of repeats) b/n restriction enzyme sites.