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NUTR 3330 (14)
Lecture

VITAMIN B5.docx

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Department
Nutrition
Course
NUTR 3330
Professor
Alison Duncan
Semester
Fall

Description
VITAMIN B 5 PANTOTHENIC ACID ABSORPTION - very important in metabolism - present in foods in various bound forms - intestinal enzymes cleave free pantothenic acid for absorption COENZYME STRUCTURE - part of 2 major coenzymes 1. Coenzyme A (CoA) 2. Acyl Carrier Protein (ACP) - action occurs at the –SH group Coenzyme A - CoASH - synthesized from cysteine, pantothenic acid & ATP SH – Pantothenic Acid - ATP Overall Metabolic Role - acetyl transfer reactions (2 carbon): connect to SH groups - acetyl CoA = central to nutrient metabolism - many anabolic and catabolic fates o TCA cycle, FA oxidation, acetylation reaction CoA Transferring Acetyl Groups – Examples 1. OXIDATIVE DECARBOXYLATION - Pyruvate → Acetyl CoA - TCA Cycle – needs vitamins thiamine (B ), 1iboflavin (B ),2thiamine (B ),3biotin 2. FATTY ACID OXIDATION - beta-oxidation - FA degraded to acetyl CoA 3. KETONE BODY FORMATION - fat metabolism → acetyl CoA → ketone bodies - used as fuel when glucose is limiting 4. OTHER CARBOXYLIC REACTIONS - amino acid catabolism - many acyl CoA intermediates 5. SYNTHETIC REACTIONS - cholesterol synthesis o HMG CoA reductase – rate limiting enzyme VITAMIN B 5 PANTOTHENIC ACID Acyl Carrier Protein (ACP) - B5is a prosthetic group - contains reactive SH group (cysteine) -
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